Fourth film in the series based on the popular computer game. Milla Jovovich reprises her role as Alice, who continues to fight against the Umbrella Corporation. Following new information, she heads to Los Angeles where she seeks out any survivors of the T-virus epidemic. Characters Jill Valentine (Sienna Guillory) and Claire Redfield (Ali Larter), who appeared previously in the series, are back to help defeat the Undead. The group of survivors attempt to strengthen their numbers and find refuge, but can they escape the city which is invested with zombies?

Las Vegas means fun in the sun. Well...at least the sun is still there. Except for a few rusting landmarks, it looks pretty much like the rest of the desert - or the whole country, for that matter. The crowds are now flesh-eating zombies: the mass undead, the oozing, terrifying sludge of what remains. Here, the newly upgraded Alice, along with her crew (Oded Fehr, Mike Epps, Ali Larter, Ashanti) will make a final stand against evil - with one goal: to turn the undead...dead again.

California 1860 and prospector Daniel Dillon (Peter Mullan) has made a fortune in gold and is now running Kingdom Come, a small town built in the heart of the Sierra mountains. He wants to turn the town into a thriving city and to this end he asks Dalglish (Wes Bentley), an engineer plotting the course of the Pacific Railroad Expedition, to survey the surrounding area. But then Dillon's wife (Nastassja Kinski) and twenty-year-old daughter (Sarah Polley), both of whom he had traded for his goldmine years before, arrive in town asking for help. Dillon is overcome with guilt, and leaves his mistress Lucia (Milla Jovovich) in order to seek his wife's forgiveness. Lucia herself then takes up with Dalglish, who tells Dillon that the railroad will not be passing through his town, thereby causing the increasingly-unhinged prospector to reach for his rifle....